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Therefore, they are nowadays recommended as first line therapy in patients with T2DM and atherosclerotic cardiovascular disease to reduce events, regardless of baseline or target HbA1c and concomitant glucose-lowering medication according to the 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes [31]

IDE exhibits reduced abundance concomitant with elevated CNS activity of GSK3 in diabetic murine models [64]

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines

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More on that in the side-effect section